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Fig. 2 | Virology Journal

Fig. 2

From: Hypermethylation of the glutathione peroxidase 4 gene promoter is associated with the occurrence of immune tolerance phase in chronic hepatitis B

Fig. 2

The expression patterns of GPX4 in different groups. (a) Relative mRNA level of GPX4 in PBMCs from IT, IA, LR, RA and HCs. Relative mRNA level of GPX4 was significantly lower in IT(P < 0.0001), IA(P < 0.0001), LR(P < 0.0001) and RA(P = 0.0092) than in HCs, respectively, by using the Kruskal-Wallis Test and Dunn’s test. (b)GPX4 promoter methylation level in PBMCs from IT, IA, LR, RA and HCs. GPX4 promoter methylation level was significantly higher in IT(P < 0.0001), IA(P = 0.0002), LR(P = 0.0284) and RA(P = 0.0475) than in HCs, respectively, by using the Kruskal-Wallis Test and Dunn’s test. (c) Serum GPX4 level from IT, IA, LR, RA and HCs. Serum GPX4 level was significantly lower in IT(P < 0.0001), IA(P < 0.0001), LR(P < 0.0001) and RA(P = 0.0075) than in HCs, respectively, by using the Kruskal-Wallis Test and Dunn’s test. ns, P>0.05; *, P ≤ 0.05; **, P ≤ 0.01; ***, P ≤ 0.001; ****, P ≤ 0.0001

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Virology Journal

ISSN: 1743-422X