Fig. 5
From: Mechanisms and consequences of mRNA destabilization during viral infections
Consequences of Cytosolic mRNA Decay. Widespread cytosolic mRNA decay causes RPBs to shuttle to the nucleus, where they reduce RNA PolII occupancy and transcription; cause hyper-adenylation of mRNAs (which contributes to nuclear retention); lead to read-through transcription and alternative splicing. All of this leads to an export block of mRNAs, so that mRNAs are trapped in the nucleus