NKD type | Gene mutation | NK cell alteration | Viral Infection susceptibility | References |
---|---|---|---|---|
cNKD | GATA2 | Normal or low NK cell number + decreased NK cell lytic function + absent or severe reduction in CD56bright | VZV, HSV, CMV, HPV | |
MCM4 | low NK cell number + diminished CD56dim subset + higher prevalence of the CD56bright subset | EBV, recurrent respiratory infections | ||
MCM10 | low NK cell number + higher prevalence of the CD56bright subset | fatal vulnerability to CMV | [139] | |
GINS1 | low NK cell number + diminished CD56dim subset + higher prevalence of the CD56 bright subset | CMV | [142] | |
GINS4 | Reduction of NK cell number and function + severe Neutropenia | CMV, varicella, recurrent herpes simplex labialis and et al | [143] | |
IRF8 | low NK cell number and function + declined CD56dim subset + higher prevalence of the CD56bright subset | EBV | [140] | |
RTEL1 | severely reduced NK cell number and function | VZV | ||
fNKD | FCGR3A | Normal NK cell numbers + diminished NK cell function | EBV, HSV, HPV | [149] |