Serotype | Origin | Receptor and co-receptors | Tissue tropism | References |
---|---|---|---|---|
AAV2 | Human | HSPG, integrin αVβ5 and α5β1, HGFR, LamR, FGFR1, CD9, AAVR | Liver, SM, CNS, Kidney, Retina Heart, Lungs | |
AAV3 | Human | HSPG, LamR, FGFR1, HGFR, AAVR | Liver, HCC, SM, cochlear inner hair cells | |
AAV6 | Human | α2,3/ α2,6 N-linked SA, EGFR, HSPG, AAVR | Liver, SM, Heart, Airway, Retina | |
AAV8 | NHP | LamR, AAVR | Liver, Retina, SM, CNS, Pancreas, Kidney, Heart | |
AAV9 | Human | N-linked galactose, LamR, AAVR | Liver, Heart, SM, Pancreas, CNS, Retina, Lung, |