Fig. 5From: The artificial amino acid change in the sialic acid-binding domain of the hemagglutinin neuraminidase of newcastle disease virus increases its specificity to HCT 116 colorectal cancer cells and tumor suppression effectCytopathic effect (CPE) in various cancer cells with S519G mutant rNDV virus. S519G mutant rNDV virus was infected in colorectal cancer cells (HCT 116 and HT-29), colorectal normal cells (CCD-18Co), and various cancer cells (T98G; glioblastoma, A549; lung cancer) at an MOI of 1. At 48Â h post infection, there was no CPE in CCD-18Co, but CPE was observed in HCT 116 to form syncytia, HT-29 cells. In addition, the rNDV infection group was showed significant CPE in A519 cells but comparatively not in S519G mutant rNDV. rNDV; recombinant NDVBack to article page