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Fig. 6 | Virology Journal

Fig. 6

From: Down-regulated TAB1 suppresses the replication of Coxsackievirus B5 via activating the NF-κB pathways through interaction with viral 3D polymerase

Fig. 6

A proposed model for the TAB1 inhibition CVB5 replication. CVB5 3D polymerase interacts with TAB1 and down-regulates TAB1 expression in cells. TAB1 stimulated the phosphorylation of IκBα, thereby activating the phosphorylation of p65, which activated the expression of downstream inflammatory factors that exerted antiviral effects

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Virology Journal

ISSN: 1743-422X