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Fig. 4 | Virology Journal

Fig. 4

From: Down-regulated TAB1 suppresses the replication of Coxsackievirus B5 via activating the NF-κB pathways through interaction with viral 3D polymerase

Fig. 4

TAB1 promotes the expressions of pro-inflammatory factors and activates the NF-κB pathway. pcDNA3.1-TAB1 (pcDNA3.1 as the control) was transfected into RD cells, then infected CVB5. Cells were harvested at 24 h.p.i.. A The expressions of pro-inflammatory factors and ISGs were analyzed by RT-qPCR; B ELISA analysis of the production of TNF-α, IL-1β, IL-6, and CCL5 in the supernatant; C The expressions of NF-κB pathway proteins in cell lysates were analyzed by Western blotting; D The expressions of IFN-I pathway proteins in cell lysates were analyzed by Western blotting. Data are represented as mean ± SD. *P ≤ 0.05, **P ≤ 0.01

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Virology Journal

ISSN: 1743-422X