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Fig. 1 | Virology Journal

Fig. 1

From: Down-regulated TAB1 suppresses the replication of Coxsackievirus B5 via activating the NF-κB pathways through interaction with viral 3D polymerase

Fig. 1

Identification of cellular proteins interacting with CVB5 3D polymerase. A GO functional enrichment analysis of the 116 differentially expressed proteins (BP, CC, and MF). A lower p-value indicates higher data reliability; B KEGG enrichment analysis of the 116 differentially expressed proteins. A lower p-value indicates higher data reliability; C The 35 significantly differentially expressed proteins clustering analysis between the CVB5 3D polymerase groups and controls (the Fold Change > 2.0 and p-value < 0.05). The red or blue colors represent significantly up-regulated or down-regulated proteins, respectively; D Protein–protein interaction (PPI) network of the 35 differentially expressed proteins. Green, red, and blue represent gene neighborhoods, gene fusions, and gene co-occurrence, respectively; E Volcano plots of the top 10 up or down-regulated proteins. Red dots for the significantly up-regulated proteins, Blue dots for the significantly down-regulated proteins, Gray dots for the nondifferential expressed proteins

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Virology Journal

ISSN: 1743-422X