Systemic perturbations in amino acids/amino acid derivatives and tryptophan pathway metabolites associated with murine influenza A virus infection

Al-Shalan, Huda A. M.; Zhou, Lu; Dong, Zhifan; Wang, Penghao; Nicholls, Philip K.; Boughton, Berin; Stumbles, Philip A.; Greene, Wayne K.; Ma, Bin

doi:10.1186/s12985-023-02239-0

Virology Journal

Table 1 Univariate analyses of changes in the amino acid concentrations in blood plasma between control and infected mice at 7, 14, and 21 dpi

From: Systemic perturbations in amino acids/amino acid derivatives and tryptophan pathway metabolites associated with murine influenza A virus infection

Amino acid	Changes in amino acid concentrations between control and infected mice
Amino acid	Change at 7 dpi (µM)	p	Change at 14 dpi (µM)	p	Change at 21 dpi (µM)	p
1-Methylhistidine	5.98	0.014	0.36	0.18	− 0.14	0.38
3-Methylhistidine	− 0.41	0.28	0.58	0.03	− 0.15	0.41
4-Hydroxyproline	− 6.69	0.026	− 0.70	0.31	3.19	0.06
5-Oxoproline	127.12	< 0.01	61.37	0.21	81.92	0.51
Alanine	− 466.63	0.02	− 260.63	0.11	197.04	0.11
α-Aminobutyric acid	12.72	0.016	− 1.18	0.03	− 1.32	0.10
Aminoadipic acid	3.02	0.14	− 4.26	0.01	0.43	0.44
Arginine	− 41.81	0.026	− 36.89	0.16	− 18.71	0.28
Asparagine	− 26.80	0.029	− 7.98	0.22	21.73	0.09
Aspartic acid	− 2.94	0.14	− 42.08	0.23	53.67	0.08
β-Alanine	− 0.37	0.30	− 3.08	0.19	8.31	0.111
Citrulline	− 30.66	< 0.01	− 2.92	0.42	23.74	0.09
Cysteine	− 24.76	< 0.01	9.88	0.38	− 26.96	0.14
Ethanolamine	− 0.49	0.34	5.86	0.12	3.35	0.07
γ-Aminobutyric acid	ND	NA	− 0.26	0.26	0.43	0.18
Glutamic acid	− 12.71	0.06	− 42.77	0.24	95.66	0.11
Glutamine	107.76	0.03	21.94	0.39	198.87	0.023
Glutathione	− 1.99	0.32	− 29.19	0.12	7.94	0.01
Glycine	− 64.36	0.01	− 47.44	0.24	144.27	0.02
Histidine	− 13.54	0.11	12.38	0.16	26.24	0.06
Isoleucine	− 6.03	0.25	− 23.66	0.05	− 4.86	0.34
Leucine	15.63	0.16	− 18.71	0.19	− 2.76	0.44
Lysine	37.40	0.26	− 34.39	0.26	− 20.58	0.36
Methionine	− 11.02	0.04	− 14.32	< 0.01	3.30	0.10
Ornithine	− 28.95	0.05	− 44.42	0.27	81.26	0.13
Phenylalanine	4.75	0.28	− 6.70	0.23	42.11	0.08
Proline	− 84.63	0.02	− 27.52	0.21	50.40	0.17
Serine	− 91.98	0.06	− 12.90	0.32	61.95	0.05
Taurine	1223.15	< 0.01	− 307.35	0.29	631.54	0.08
Threonine	− 42.72	0.07	− 77.87	0.01	33.66	0.09
Tryptophan	1.19	0.46	− 3.77	0.39	− 4.08	0.33
Tyrosine	− 39.46	0.03	− 6.24	0.37	38.29	0.11
Valine	− 10.56	0.09	− 45.37	0.02	18.12	0.23

Bold numbers indicate a increase in IAV infection, whereas italic numbers indicate an decrease (p < 0.05) in IAV infection. ND Not detected, NA Not applicable

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ISSN: 1743-422X

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