Fig. 2

Top20 canonical pathways modulated in PIEs following the RVC infection vs control (non-infected PIEs) (performed using Qiagen IPA). Canonical pathways listed are as followed: Thrombin signaling, role of tissue factor in cancer, colorectal cancer metastasis signaling, nucleotide excision repair (NER), integrin-linked kinase (ILK) Signaling, cardiac hypertrophy signaling, RHOGDI signaling, estrogen-mediated S-phase entry, senescence pathway, aryl hydrocarbon receptor signaling, signaling by Rho family GTPases, actin cytoskeleton signaling, mismatch repair in eukaryotes, cyclins and cell cycle regulation, endothelin-1 signaling, interferon signaling, microRNA biogenesis signaling, cell cycle control of chromosomal replication, role of BRCA1 in DNA damage response, kinetochore metaphase signaling. Canonical pathway analysis was conducted using the IPA library and shows the most significant contributions through the input data set. For canonical pathway analysis the—log (p-value) > 1.3 was taken as threshold, the z-score > 2 was defined as the threshold of significant activation, whilst z-score <  − 2 was defined as the threshold of significant inhibition. Bars indicate the activation z-score; blue symbols represent p values in log10 format