Fig. 5
From: DNA damage response(DDR): a link between cellular senescence and human cytomegalovirus
Model of the host DNA damage response induced by HCMV infection. Efficient replication of HCMV requires DDR centered on ATM and E2F1. HCMV infection can activate multiple DDR proteins, including ATM and the downstream effector proteins p53 and H2AX. IE1, IE2, pp71, and pUL97 of HCMV can inactivate RB family members, leading to dysregulation of E2F1 proteins and subsequent production of DSBs.