Fig. 4
From: DNA damage response(DDR): a link between cellular senescence and human cytomegalovirus
The model of HCMV-induced senescence. Human cytomegalovirus (HCMV) has two modes of infection: latent and productive. (A) In the latent infection, cells from the myeloid lineage are considered as primary sites. Long exposure to HCMV enables terminal differentiation of T cells leading to accumulation of exhausted CD28 T cells, which secrete TNF-α and IFN-γ to promote inflamm-aging. (B) In the productive infection, HCMV-infected cells show senescence phenotype, including cell cycle arrest and SASP.