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Fig. 3 | Virology Journal

Fig. 3

From: Oxidative stress and ROS-mediated cellular events in RSV infection: potential protective roles of antioxidants

Fig. 3

ROS-dependent NET release and NETosis by RSV-infected neutrophils. RSV F glycoprotein stimulates TLR4 which may activate the Raf/MEK/ERK pathway and subsequent NADPH oxidase complexes, leading to ROS production. ROS can promote the separation and loss of the nuclear membrane and activate PAD4-mediated histone citrullination to allow chromatin decondensation. RIPK1/RIPK3/MLKL induces cytomembrane rupture and contributes to NETosis. PI3K/AKT and p38 MAPK are also involved in NETosis, although the mechanism is not fully understood

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Virology Journal

ISSN: 1743-422X