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Table 2 Factors associated with study participants within genetic transmission networks in Ningbo, China

From: HIV-1 drug resistance and genetic transmission network among newly diagnosed people living with HIV/AIDS in Ningbo, China between 2018 and 2021

Factors

Within genetic transmission networks

n (%)

Univariate analysis

Multivariate analysis

χ2

P value

OR(95%CI)

P value

Gender

 

2.231

0.135

  

Male

375(84.5)

  

1.000

 

Female

69(15.5)

  

1.252(0.815 ~ 1.923)

0.306

Age (years)

 

4.778

0.029

  

< 25

55(12.4)

  

1.00

 

25~

153(34.5)

  

1.248(0.814 ~ 1.914)

0.310

40~

152(34.2)

  

1.322(0.777 ~ 2.247)

0.303

≥ 60

84(18.9)

  

2.038(1.072 ~ 3.872)

0.030

Marital status

 

1.606

0.448

  

Single

161(36.3)

  

1.000

 

Married

200(45.0)

  

0.918(0.619 ~ 1.363)

0.673

Divorce or death

83(18.7)

  

0.784(0.502 ~ 1.226)

0.286

Education level

 

0.040

0.842

  

Middle school or less

273(61.5)

  

1.000

 

High school or above

171(38.5)

  

1.175(0.851 ~ 1.621)

0.328

Nationality

 

1.261

0.262

  

Han

429(96.6)

  

1.000

 

Others

15(3.4)

  

0.721(0.366 ~ 1.420)

0.344

Location

 

1.873

0.171

  

Local

204(45.9)

  

1.000

 

Non local

240(54.1)

  

0.950(0.712 ~ 1.267)

0.728

Route of infection

 

3.257

0.196

  

Heterosexual transmission

248(55.9)

  

1.000

 

Homosexual transmission

195(43.9)

  

0.888(0.642 ~ 1.228)

0.472

Others

1(0.1)

  

0.619(0.058 ~ 6.588)

0.691

Number of sexual partners in a life time

 

5.253

0.022

  

<2

137(30.9)

  

1.000

 

2~

307(69.1)

  

0.747(0.549 ~ 1.017)

0.064

HIV-1 genotypes

 

27.539

< 0.001

  

CRF01_AE

112(25.2)

  

1.000

 

CRF07_BC

211(47.5)

  

2.147(1.582 ~ 2.914)

< 0.001

CRF08_BC

30(6.8)

  

1.459(0.840 ~ 2.536)

0.180

C

25(5.6)

  

1.669(0.922 ~ 3.022)

0.091

CRF55_01B

25(5.6)

  

2.217(1.201 ~ 4.091)

0.011

Others*

41(9.2)

  

1.815(0.936 ~ 2.981)

0.069

CD4,cell/ul

 

6.581

0.037

  

< 200

155(34.9)

  

1.000

 

200~

250(56.3)

  

1.305(0.982 ~ 1.735)

0.067

≥ 500

39(8.8)

  

0.933(0.584 ~ 1.491)

0.773

Transmitted drug resistance

 

2.483

0.115

  

Sensitive

423(95.3)

  

1.000

 

Resistance

21(4.7)

  

1.384(0.784 ~ 2.444)

0.262

  1. *: B,URFs, CRF85_BC,CRF01_BC,CRF59_01B, CRF67_01B and CRF68_01B