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Table 4 Comparison of clinical outcomes between autoantibody-negative patients and ANA, IgM aβ2-GPI, IgG aCL, and IgM aCL/IgM aβ2-GPI patients

From: Prevalence, clinical significance, and persistence of autoantibodies in COVID-19

 

Control group

(n = 202)

ANA

(n = 5)

IgM aβ2-GPI

(n = 26)

IgG aCL

(n = 6)

IgM aCL/IgM aβ2-GPI

(n = 5)

P

P`

P``

P```

In-hospital mortality, No.

51 (25.2)

1 (20.0)

5 (19.2)

4 (66.7)

0

> 0.99

0.668

0.072

0.442

Thromboembolism, No.

13 (6.4)

0

2 (7.7)

2 (33.3)

0

> 0.99

> 0.99

0.087

> 0.99

Mechanical ventilation, No.

82 (40.6)

0

11 (42.3)

5 (83.3)

3 (60.0)

0.171

> 0.99

0.095

0.681

ECMO support, No.

6 (3.0)

0

1 (3.8)

0

0

> 0.99

> 0.99

> 0.99

> 0.99

CRRT, No.

12 (5.9)

0

1 (3.8)

2 (33.3)

0

> 0.99

> 0.99

0.07

> 0.99

Length of stay, median, d

18.0

(13.0–30.0)

13.0

(12.0–17.0)

18.0

(13.0–25.0)

2.0

(22.0–28.0)

14.0

(13.0–21.0)

0.13

0.694

0.426

0.412

  1. Abbreviations: ANA, antinuclear antibodies; aβ2-GPI, anti-β2 Glycoprotein1 antibody; aCL, anti-Cardiolipin antibody; CRRT, Continuous renal replacement therapy; P, ANA-positive and control group; P`, IgM aβ2-GPI-positive and control group; P``, IgG aCL-positive and control group; P```, IgM aCL/IgM aβ2-GPI-positive and control group; IQR, interquartile range; ECMO, Extracorporeal membrane oxygenation
  2. Data are expressed as median (interquartile range) or number (%)