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Fig. 2 | Virology Journal

Fig. 2

From: Unveiling the biology of defective viral genomes in vitro and in vivo: implications for gene expression and pathogenesis of coronavirus

Fig. 2

Reproducibility of DVGs. (A)-(C) The overall reproducibility of DVGs for BCoV in BCoV-infected cells, MHV-A59-infected cells and mice. (D)-(F) The reproducibility of 5’3’DVG, Δ3’DVG and Δ5’DVG in BCoV-infected cells. (G)-(I) The reproducibility of 5’3’DVG, Δ3’DVG and Δ5’DVG in MHV-A59-infected cells. (J) The reproducibility of Δ5’DVG in MHV-A59-infected mice. Reproducibility was measured for transcripts with a read count of ≥ 5 based on RNA (BCoV RNA1 and BCoV RNA2) collected from the two biological replicates. The reproducibility is measured in reads per kilobase per million mapped sequence reads (RPKM) and evaluated by Spearman’s correlation coefficient. R = 0.000-0.3999, low reproducibility; R = 0.4000-0.5999, moderate reproducibility; R = 0.6000-1.0000, high reproducibility

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