Table 2 The variations of HPV16 E6 and E7 genes
From: Genetic variation of E6 and E7 genes of human papillomavirus type 16 from central China
Positions | E6 | E7 | N (176) | ||||||||||||||||||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
94 | 95 | 109 | 131 | 137 | 153 | 158 | 173 | 176 | 178 | 184 | 185 | 188 | 216 | 241 | 276 | 292 | 306 | 335 | 350 | 387 | 395 | 426 | 442 | 489 | 553 | 597 | 646 | 647 | 663 | 666 | 753 | 760 | 781 | 790 | 823 | 843 | 846 | ||
Reference | G | A | T | A | T | C | C | C | G | T | A | T | G | T | T | A | T | A | C | T | C | G | A | A | G | G | G | A | A | G | G | G | T | G | C | G | T | T | 8 |
16HB01 | – | – | – | – | – | – | – | – | – | G | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | G | – | – | – | – | – | – | – | – | C | 58 |
16HB02 | – | – | – | – | – | – | – | – | – | G | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | G | – | – | – | – | – | – | – | C | C | 24 |
16HB03 | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | C | – | – | – | – | – | 10 |
16HB04 | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | T | – | – | – | 6 |
16HB05 | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | A | – | – | – | – | – | – | – | 6 |
16HB06 | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | G | – | – | – | – | – | – | – | – | – | – | – | – | – | – | A | – | – | – | – | – | – | – | 5 |
16HB07 | – | – | – | – | – | – | – | – | – | G | – | – | – | – | – | – | – | – | – | – | – | – | – | C | – | – | – | – | G | A | – | – | – | – | – | – | – | C | 5 |
16HB08 | – | – | – | – | – | – | – | – | – | G | – | G | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | G | – | – | – | – | – | – | – | – | C | 5 |
16HB09 | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | G | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | 3 |
16HB10 | – | – | – | – | – | – | – | – | – | – | – | – | – | – | G | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | A | – | – | – | – | – | – | – | 3 |
16HB11 | – | – | – | C | – | – | – | – | – | G | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | G | – | – | – | – | – | – | – | – | C | 2 |
16HB12 | A | – | – | – | – | – | – | – | – | A | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | A | – | – | – | – | – | – | – | 2 |
16HB13 | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | C | – | – | – | – | C | – | – | – | – | – | – | – | – | – | 2 |
16HB14 | – | – | – | – | – | – | – | – | – | – | – | – | C | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | 2 |
16HB15 | – | – | – | – | – | – | – | – | – | – | – | G | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | A | – | – | – | – | – | – | – | 2 |
16HB16 | A | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | G | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | 2 |
16HB17 | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | T | – | – | – | – | C | – | – | – | C | – | – | – | – | – | – | – | – | – | – | 2 |
16HB18 | A | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | 2 |
16HB19 | – | – | – | – | – | – | – | T | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | C | – | – | – | – | – | 1 |
16HB20 | – | – | – | – | G | – | – | – | – | G | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | G | – | – | – | – | – | – | – | – | C | 1 |
16HB21 | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | C | – | – | – | – | – | – | A | – | – | – | – | – | – | – | 1 |
16HB22 | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | C | – | – | – | – | – | – | C | – | – | – | C | – | – | – | – | – | – | – | – | – | – | 1 |
16HB23 | A | – | – | – | – | – | – | – | – | A | – | – | – | – | – | – | – | C | – | – | – | – | – | – | – | – | – | – | – | – | A | – | – | – | – | – | – | – | 1 |
16HB24 | A | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | A | – | – | – | – | – | – | – | T | – | – | – | 1 |
16HB25 | – | – | – | – | – | – | – | – | – | G | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | C | 1 |
16HB26 | – | – | – | – | – | – | – | – | – | – | – | – | C | – | – | – | – | – | – | – | – | – | – | C | – | – | – | C | – | – | – | – | – | – | – | – | – | – | 1 |
16HB27 | – | – | – | – | – | – | – | – | – | G | – | – | – | – | – | – | – | – | – | – | – | T | – | – | – | – | – | – | G | – | – | – | – | – | – | – | – | C | 1 |
16HB28 | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | T | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | 1 |
16HB29 | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | G | – | – | – | – | A | – | – | C | – | – | – | – | – | – | – | – | – | – | 1 |
16HB30 | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | C | – | – | – | – | – | – | – | A | – | – | – | – | – | – | – | 1 |
16HB31 | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | G | – | – | – | – | – | – | – | – | – | – | – | C | – | – | – | – | – | – | 1 |
16HB32 | – | – | – | – | – | – | – | – | A | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | C | C | C | – | – | – | – | 1 |
16HB33 | A | – | – | – | – | – | – | – | – | G | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | A | – | – | – | – | – | – | – | 1 |
16HB34 | – | – | – | – | – | – | A | – | – | G | – | G | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | G | – | – | – | – | – | – | – | – | C | 1 |
16HB35 | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | G | – | – | – | – | – | – | C | C | C | 1 |
16HB36 | A | G | – | – | – | – | – | – | – | A | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | A | – | – | – | – | – | – | – | 1 |
16HB37 | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | T | – | – | – | – | C | – | – | – | – | – | – | – | – | – | – | – | – | – | – | 1 |
16HB38 | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | T | G | – | – | – | – | – | T | – | – | – | – | – | – | – | – | – | – | – | – | 1 |
16HB39 | A | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | G | – | – | – | – | – | – | – | C | – | – | – | – | – | – | – | – | – | – | 1 |
16HB40 | – | – | C | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | G | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | 1 |
16HB41 | – | – | – | – | – | – | – | – | – | G | – | – | – | C | – | – | – | – | – | – | – | – | – | – | – | – | – | – | G | – | – | – | – | – | – | – | – | C | 1 |
16HB42 | – | – | – | – | – | – | – | – | – | – | G | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | 1 |
16HB43 | – | – | – | – | – | – | – | – | – | G | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | G | – | – | – | – | – | T | – | C | C | 1 |
16HB44 | – | – | – | – | – | – | – | – | A | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | C | – | – | – | – | – | 1 |
16HB45 | – | – | – | – | – | T | – | – | – | G | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | G | – | – | – | – | – | – | – | – | C | 1 |
Reference AA | K | R | F | R | L | T | L | H | D | D | I | L | E | L | A | N | C | K | H | L | P | D | K | E | R | Q | M | N | N | E | E | T | L | V | R | G | C | S | |
AA Position | 4 | 5 | 9 | 17 | 19 | 24 | 26 | 31 | 32 | 32 | 34 | 35 | 36 | 45 | 53 | 65 | 70 | 75 | 85 | 90 | 102 | 105 | 115 | 120 | 136 | 157 | 12 | 29 | 29 | 34 | 35 | 64 | 67 | 74 | 77 | 88 | 94 | 95 | |
AA Variant | – | G | – | – | V | I | M | Y | N | E | M | V | Q | P | – | S | – | T | Y | V | L | Y | T | D | K | H | I | H | S | – | – | – | – | L | C | R | – | – | |
Secondary structure | – | – | – | – | – | – | – | – | S | S | S | S | H | – | H | – | – | – | S | S | – | S | – | – | S | S | H | – | – | H | H | – | – | – | S | – | – | – | |