Table 1 Distribution of major nucleotide variation in HPV16 E6 and E7 genes based on cervical disease status
From: Genetic variation of E6 and E7 genes of human papillomavirus type 16 from central China
Gene | Nucleotide variation | Women with cervical disease status | ||||
|---|---|---|---|---|---|---|
HN | LSIL | HSIL | CC | Total | ||
n = 110 | n = 9 | n = 42 | n = 15 | n = 176 | ||
E6 | G94A | 8 | 1 | 2 | 0 | 11 |
A95G | 0 | 0 | 1 | 0 | 1 | |
T109C | 1 | 0 | 0 | 0 | 1 | |
A131C | 2 | 0 | 0 | 0 | 2 | |
T137G | 1 | 0 | 0 | 0 | 1 | |
C153T | 0 | 0 | 0 | 1 | 1 | |
C158A | 0 | 0 | 1 | 0 | 1 | |
C173T | 1 | 0 | 0 | 0 | 1 | |
G176A | 1 | 1 | 0 | 0 | 2 | |
T178G | 60 | 3 | 30 | 9 | 102 | |
T178A | 3 | 0 | 1 | 0 | 4 | |
A184G | 0 | 0 | 1 | 0 | 1 | |
T185G | 5 | 0 | 1 | 2 | 8 | |
G188C | 1 | 1 | 1 | 0 | 3 | |
T216C | 1 | 0 | 0 | 0 | 1 | |
T241G | 2 | 0 | 1 | 0 | 3 | |
A276G | 2 | 0 | 1 | 2 | 5 | |
T292C | 1 | 0 | 0 | 0 | 1 | |
A306C | 1 | 0 | 0 | 0 | 1 | |
C335T | 2 | 0 | 2 | 0 | 4 | |
T350G | 8 | 0 | 1 | 1 | 10 | |
C387T | 1 | 0 | 0 | 0 | 1 | |
G395T | 0 | 0 | 0 | 1 | 1 | |
A426C | 0 | 0 | 0 | 1 | 1 | |
A442C | 7 | 2 | 4 | 0 | 13 | |
G489A | 0 | 0 | 0 | 1 | 1 | |
G553T | 0 | 0 | 1 | 0 | 1 | |
E7 | G597A | 0 | 0 | 1 | 0 | 1 |
A646C | 6 | 1 | 0 | 1 | 8 | |
A647G | 59 | 3 | 30 | 9 | 101 | |
G663A | 2 | 0 | 3 | 0 | 5 | |
G666A | 13 | 1 | 4 | 5 | 23 | |
G753C | 1 | 1 | 0 | 0 | 2 | |
T760C | 10 | 2 | 1 | 0 | 13 | |
G781C | 0 | 1 | 0 | 0 | 1 | |
C790T | 4 | 0 | 4 | 0 | 8 | |
G823C | 1 | 0 | 0 | 0 | 1 | |
T843C | 15 | 1 | 6 | 4 | 26 | |
T846C | 60 | 3 | 30 | 9 | 102 | |
Total | 279 | 21 | 127 | 46 | 473 | |