Fig. 2

Major pattern recognition receptors in the innate immune response to EBV. Abbreviations: EBV, Epstein‒Barr virus; TLRs, Toll-like receptors; MyD88, myeloid differentiation primary response 88; TRIF, TIR-domain-containing adapter protein-inducing interferon-β; RLRs: retinoic acid-inducible gene-I-like receptors; MAVS, mitochondrial antiviral signaling; cGAS: cyclic GMP-AMP synthase; cGAMP, cyclic GMP-AMP; STING, stimulator of interferon genes; ER, endoplasmic reticulum; IRF, interferon regulatory factor