From: The key amino acids of E protein involved in early flavivirus infection: viral entry
Amino acids | Amino acid localization | Structural position/functional site | Viruses | References |
---|---|---|---|---|
154 (DENV, 153) | Domain I | Glycosylation site | DENV, WNV, JEV, ZIKV | |
398, 405, 429, 436 | Stem region | α-helix in stem region | DENV | [48] |
424–445 | Stem region | Stem region | ZIKA | [49] |
138 | Domain I | Virulence attenuated site | JEV | |
390 | Domain III | RGD motif | MVE | [54] |
277 | Between domain I & domain II | Hinger region | MVE | [55] |
325, 380 | Domain III | Top layer of virion | YFV | |
19–22 | Domain I | HspA9 binding motif | TMUV | [58] |
245–252 | Domain II | |||
304 | Domain III | Virulence attenuated site | TMUV | [59] |
367 | Domain III | Virulence attenuated site | TMUV | [60] |
144 | Domain I | Participating domain I-domain III interaction | JEV | [61] |
319 | Domain III | |||
258 | Domain II | Potentially participating post-fusion step | ||
410 | Domain III | |||
291 | Domain III | Participate in electrostatically mediated interactions | DENV | [62] |
295 |