Organ system | Symptom | Frequency (%) | Studies reported | |
---|---|---|---|---|
Median | IQR | |||
Cerebrovascular | Headache | 8.2% | 7.1–16.0 | 7 |
 | Confusion | 9.1% | – | 1 |
 | Dizziness | 9.4% | – | 1 |
Eye* | – | – | – | 0 |
Ear, Nose, Throat | Nasal Congestion/ Rhinorhea | 16.7% | 6.9–61.5 | 4 |
 | Sore throat | 11.1% | 5.9–16.5 | 4 |
 | Sputum Production | 30.2% | 10.0–39.7 | 4 |
 | Tonsil swelling | 2.0% |  |  |
Chest/Pulmonary | Cough | 71.4% | 46.7–73.1 | 12 |
 | Shortness of breath | 36.7% | 19.0–56.5 | 11 |
 | Hemoptysis | 4.9% | 1.0–5.1 | 4 |
 | Chest pain | 2.0% | – | 1 |
 | Chest distress | 23.8% | – | 1 |
Gastrointestinal | Loss of appetite | 39.9% | 12.2–49.5 | 3 |
 | Nausea/ Vomiting | 12.7% | 4.0–19.5 | 6 |
 | Diarrhea | 8.0% | 3.2–11.8 | 10 |
 | Abdominal pain | 4.4% | 4.3–5.8 | 3 |
Musculoskeletal | Fatigue | 66.9% | 49.9–73.6 | 4 |
 | Myalgia/Arthralgia | 23.1% | 14.6–33.5 | 9 |
Dermatological | Rash | 0.2% | Â | 1 |
*Eye | None of the original searches contained data on ocular signs and symptoms. A cohort [57], however, focused on ocular signs and symptoms revealed: eye pain (19.4%), photophobia (13.9%), flashes or floaters (11.8%), blurring of vision (11.1%), and eye redness (10.4%) | Â | Â | Â |
Disease severity classification | Features (as per CDC guidelines) | Â | Â | Â |
---|---|---|---|---|
Asymptomatic/presymptomatic | Patients who test positive for SARS-CoV-2 but have no symptoms suggestive for SARS-cov-2 infection | Â | Â | Â |
Mild Illness | Patients having any of the various signs or symptoms of SARS-CoV-2 infection but do not have shortness of breath, dyspnea or abnormal chest imaging | Â | Â | Â |
Moderate Illness | Individuals who show signs of lower respiratory disease on clinical assessment or imaging and have an oxygen saturation (SpO2) of ≥ 94% on room air at sea level |  |  |  |
Severe Illness | Individuals with SpO2 < 94% on room air at sea level, a ratio of arterial partial pressure of oxygen to fraction of inspired oxygen (PaO2/FiO2) < 300 mm Hg, respiratory frequency > 30 breaths/min, or lung infiltrates > 50% |  |  |  |
Critical Illness | Individuals having respiratory failure, septic shock, and/or multiple organ dysfunction | Â | Â | Â |