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Fig. 4 | Virology Journal

Fig. 4

From: Small molecules block the interaction between porcine reproductive and respiratory syndrome virus and CD163 receptor and the infection of pig cells

Fig. 4

3-(morpholinosulfonyl)anilino or 3-(piperidinylsulfonyl)anilino Alone Does Not Inhibit PRRSV Infection and B7 Post-Treatment Significantly Inhibits PRRSV Infection. a Molecular structures of B7-A7 and B7-A8. b Titration assay results for the culture media of PAMs treated with B7, B7-A7, or B7-A8 and infected by PRRSV strain V-2332. Bars = mean ± SD, n = 3. ***: P < 0.001. ns: non-significant. c qRT-PCR for PRRSV in total RNAs extracted from PAMs infected by PRRSV VR-2332 and treated with 15 μM of B7 compound at pre and/or post-inoculation. Values are normalized with GAPDH of PAMs. Bars = mean ± SD, n = 3. *: P < 0.05. ns: non-significant. d Titration assay results for PRRSV in the culture media of PAMs treated as described in (c). Bars = mean ± SD, n = 3. ***: P < 0.001. ns: non-significant

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Virology Journal

ISSN: 1743-422X