Table 2 TOP 15 up- and downregulated DEGs in the vaccinated groups. RNA-encoding DEGs and DEGs connected to the neuroendocrine-immune system are bolded and underlined, respectively
From: Response to a DNA vaccine against the H5N1 virus depending on the chicken line and number of doses
Ross[2x] | WL[2x] | Rosa[2x] | Rosa[1x] | ||||
|---|---|---|---|---|---|---|---|
Up-regulated | |||||||
Gene Symbol | FC | Gene Symbol | FC. | Gene Symbol | FC | Gene Symbol | FC |
GAL7 | 14,7 | SNORD35 | 2,03 | MX1 | 2,50 | SNORA56 | 3,05 |
GAL1 | 9,4 | GRM8 | 2,02 | GVIN1 | 2,30 | MHC region | 2,88 |
GAL2 | 9,1 | USP6NL | 2,00 | ISG12–2 | 2,23 | U11 | 2,68 |
GAL6 | 8,3 | MGST2 | 1,84 | MHC | 2,01 | MIR1743 | 2,51 |
LECT2 | 6,8 | MHC class I | 1,80 | ncRNA | 2,01 | – | 2,32 |
GVIN1 | 6,3 | gga-mir-147 | 1,76 | ncRNA | 2,01 | MIR1596 | 1,96 |
TCRDV | 4,9 | OAT | 1,69 | ncRNA | 2,01 | C9ORF58 | 1,96 |
6TBGa-2 | 3,4 | SLC2A9 | 1,68 | ncRNA | 2,01 | MIR7B | 1,93 |
SERPINB10 | 3,1 | C2H6ORF105 | 1,53 | LAMA1 | 1,93 | SNORA66 | 1,89 |
LOC100858620 | 2,9 | BORCS5 | 1,50 | ZP1 | 1,83 | SNORA23 | 1,87 |
RHCE | 2,8 | NONGGAT007307 | 1,50 | TSPO2 | 1,82 | MIR1680 | 1,87 |
S100A9 | 2,6 | NADB-LER2 | 1,49 | LAG3 | 1,77 | SNORD90 | 1,87 |
ACKR2 | 2,5 | STAM2 | 1,47 | ARHGEF39 | 1,73 | RPL23 | 1,84 |
SNORD24 | 2,4 | TIFA | 1,42 | CCR8 | 1,72 | SNORD14 | 1,82 |
TIMMDC1 | 2,3 | CCLi9 gene | 1,42 | LYGL | 1,72 | ND4L | 1,81 |
Down-regulated | |||||||
DDX60 | -2,9 | IGLV | −5,12 | – | −3,77 | PRED.: LOC107050276 | −4,28 |
DDX60 | −2,9 | GDPD2 | −1,85 | – | −2,07 | CIAO1 | −2,98 |
snoRNA GGN47 | −2,9 | LRRC4C | −1,77 | GIMAP7L5 | −2,00 | SLC8A3 | −2,25 |
NTMT1 | −2,8 | SNORA56 | −1,65 | IL28RA | −1,97 | PRED.: MICA | −2,21 |
EYA1 | −2,7 | IFNA | −1,58 | MIR1637 | −1,82 | PRED.: CYP2J2L2 | − 1,97 |
RRBP1 | −2,4 | MIR1636 | −1,55 | TDRD5 | −1,64 | CHIR-B5 | −1,79 |
GPR158 | −2,2 | AICDA | −1,53 | GRTP1 | −1,60 | LOC431321 | −1,78 |
LRRC3B | −2,2 | ACTA2 | −1,52 | MRPL13 | −1,59 | PRED.: LOC100859143 | −1,77 |
ALDH1A3 | −2,1 | LOC100858370 | −1,46 | CACNB4 | −1,58 | PTPRZ1 | −1,75 |
STXBP5L | −2,1 | MIR1648 | −1,43 | ABI3BP | −1,56 | COCH | −1,70 |
IFIT5 | −2,0 | ACTG2 | −1,41 | VH57–1 | −1,51 | Mt_tRNA | −1,69 |
OASL | −1,9 | SLC8A3 | −1,41 | LOC107050168 | −1,51 | PRED.: TMEM98 | −1,67 |
MDK | −1,8 | LOC776492 | −1,40 | LACC1 | −1,50 | LECT1 | −1,65 |
MI0005509 | −1,8 | OLFML3 | −1,39 | LOC107055505 | −1,45 | PRED.: OR14A16L45 | −1,64 |
SNORD18 | −1,7 | TMC6 | −1,37 | KCNK12 | −1,45 | SLC38A3 | −1,63 |