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Table 3 Antigenic characterization of wild-type and mutant H1N1 influenza A viruses by MN assay

From: Influenza A virus hemagglutinin mutations associated with use of neuraminidase inhibitors correlate with decreased inhibition by anti-influenza antibodies

H1N1 virus

mAbs against CA/04:

Human sera against CA/04:

28665

28666

28667

28668

Donor 1

Donor 2

Donor 3

CA/04V152I

3a

0

2

−1

0

−1

0

CA/04G155E

−6

0

1

−9

−6

− 9

− 8

CA/04S162N

4

0

5

−1

0

0

0

CA/04S183P

0

0

−1

− 1

0

− 1

0

CA/04D222G

−4

0

3

−8

−4

−4

−5

  1. aValues represent the differences between the neutralizing mAb titers (reciprocals of antibody dilutions that neutralized 50 TCID50s of virus) in the reactions with the wild-type CA/04 and mutant H1N1 viruses in log2 units