Table 2 Sensitivity, specificity, positive predictive value and negative predictive value of MAb-ELISA at different cut-off levels compared to PRNT70
From: Monoclonal antibody-based capture ELISA in the diagnosis of previous dengue infection
MAb-ELISA (P/N ratio) | Sensitivity (95% C.I) | Specificity (95% C.I) | Positive predictive value (95% C.I) | Negative predictive value (95% C.I) |
|---|---|---|---|---|
> 1 | 97.84 (95.02–99.29%) | 61.99 (55.24–68.42%) | 72.90 (69.43–76.12%) | 96.48 (91.96–98.50%) |
> 1.5 | 96.97 (93.86–98.77%) | 81.00 (75.19–85.95%) | 84.21 (80.23–87.51%) | 96.24 (92.48–98.15%) |
> 2 | 94.37 (90.57–96.97%) | 87.33 (82.21–91.41%) | 88.62 (84.61–91.68%) | 93.69 (89.73–96.19%) |
> 3 | 91.34 (86.95–94.63%) | 90.95 (86.37–94.38%) | 91.34 (87.39–94.14%) | 90.95 (86.84–93.87%) |
> 4 | 88.31 (83.45–92.15%) | 91.86 (87.43–95.10%) | 91.89 (87.89–94.65%) | 88.26 (84.03–91.48%) |
> 5 | 84.85 (79.56–89.21%) | 95.02 (91.27–97.49%) | 94.69 (90.90–96.95%) | 85.71 (81.53–89.07%) |