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Table 1 The major amino acid substitutions among the seven related strains of DENV-3 from China, Laos, India and Singapore as compared with the standard strain H87

From: Molecular characterization and phylogenetic analysis of a dengue virus serotype 3 isolated from a Chinese traveler returned from Laos

Aa position

H87

YNPE3

Balotra87_s

YN01

UI17760

D3/SG/CT7/2012

Philippines 1956

China 2013

India 2013

China 2013

Laos 2010

Singapore 2012

GV

GIII

GIII

GII

GII

GI

ORF

Protein

      

Capsid

 35

35

R

K

K

   

 86

86

K

R

    

 108

108

M

I

I

   

Envelope

 361

81

I

V

V

  

T

 404

124

S

L

P

  

L

 412

132

H

Y

Y

   

 420

140

I

  

T

T

 

 434

154

E

  

D

D

 

 444

164

S

P

P

P

P

 

 449

169

A

T

T

V

V

P

 505

225

K

E

E

E

E

V

 550

270

T

N

N

N

N

E

 551

271

T

S

S

S

S

T

 572

292

K

E

E

E

E

S

 581

301

L

T

T

  

E

 663

383

K

N

N

  

S

 671

391

R

K

K

K

K

 

 727

447

S

  

G

G

K

 732

452

I

V

V

   

NS1

 820

47

R

K

    

 821

48

V

L

L

L

L

L

 856

83

D

N

N

N

N

N

 866

93

I

T

T

   

 867

94

T

I

I

I

I

I

 871

98

E

D

    

 893

120

L

K

K

K

K

K

 912

139

S

N

N

N

N

N

 951

178

L

M

M

T

T

L

 961

188

V

  

I

I

 

 990

217

L

  

F

F

 

 1029

256

H

Y

Y

  

Y

 1061

288

S

T

T

T

T

T

 1112

339

N

S

S

   

NS2A

 1162

37

L

F

F

   

 1225

100

E

K

    

 1237

112

A

T

T

T

T

T

 1240

115

R

Q

Q

Q

Q

Q

 1267

142

T

I

    

 1275

150

V

I

I

   

 1300

175

I

V

V

V

V

 

NS3

 1504

31

F

L

L

   

 1588

115

I

T

T

   

 1829

356

V

A

A

   

 1865

392

D

E

E

   

 1910

437

D

E

    

 1925

452

V

A

A

A

A

 

 1949

476

M

T

T

 

T

T

 1962

489

W

E

    

 1964

491

E

Q

    

 1965

492

A

E

    

 2041

568

E

Q

Q

   

NS4A

 2162

70

L

I

    

 2191

99

D

E

E

   

 2192

100

V

I

I

  

I

 2240

148

V

I

I

   

NS4B

 2357

115

V

I

I

   

 2393

151

M

I

I

   

NS5

 2540

50

I

T

T

T

T

 

 2678

188

T

A

A

  

A

 2778

288

S

N

N

   

 2912

422

R

K

K

   

 3052

562

Q

L

L

   

 3075

585

K

T

T

   

 3109

619

I

V

V

   

 3129

639

L

P

P

   

 3130

640

E

G

   

A

 3253

763

T

S

S

S

S

 

 3325

835

D

N

N

   

 3354

864

L

S

P

   
  1. The GI, GII, GIII and GV represent genotype I, genotype II, genotype III and genotype V, respectively. The accession number of those related strains: H87(M93130), Balotra87_s(KU216209), YN01(KF824902), UI17760(KY849769), D3/SG/CT7/2012(KX380839). YNPE3(MF370226)
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