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Table 3 Distribution of the SW/3/06 virus in experimentally inoculated mice

From: The pathogenicity of swan derived H5N1 virus in birds and mammals and its gene analysis

Inoculation route

Dose (EID50)

Hpi

Viral titer (log10EID50/0.1 mL, mean ± standard deviation)

MLD50(EID50)

MID50(EID50)

Lung

Brain

Liver

Spleen

Kidney

I.n.

104.0

30-48

6.4 ± 0.7

1.9 ± 0.1

2.7 ± 0.6

4.2 ± 1.0

4.1 ± 0.8

2.9

1.7

I.m.

104.0

48-72

6.2 ± 0.8

1.8 ± 0.1

2.0 ± 0.4

3.6 ± 0.5

3.5 ± 1.5

  1. BALB/c mice (five per group) were inoculated intranasally or intramuscularly with 104.0 EID50/50 μl of SW/3/06 virus. To assess mouse LD50 (MLD50), the mice were inoculated with 10-fold serial dilutions of 106.0 EID50 of SW/3/06 virus (100.0 to 107.0) via the intranasal route and observed for 14 days. To assess mouse ID50 (MID50), lung tissues were collected from three inoculated mice per group at 3 dpi. The lower virus detection limit was 101.75 EID50/g.
  2. Hpi, hour post infection.
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Virology Journal

ISSN: 1743-422X