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Table 1 Analysis of the clinical data for 423 hospitalized patients

From: Distribution of enteroviruses in hospitalized children with hand, foot and mouth disease and relationship between pathogens and nervous system complications

 

general

severely

critically

fatal

p value

Total

Case number (n)

189

197

28

9

 

423

Number of cases in which a pathogen was detected (n)

85(45.0%)

71(36%)

16(57.1%)

5(55.6%)

0.076

177(41.8%)

Age*(Years) â‘ 

3.045 ± 2.102

2.546 ± 1.730

1.893 ± 1.397

2.056 ± 1.509

0.003

 

Gender(male, n)

125(66.1%)

114(57.9%)

25(89.3%)

8(88.9%)

0.003

272(64.3%)

Region(from countryside, n)

116(61.4%)

124(62.9%)

23(82.1%)

5(55.6%)

0.185

268(63.4%)

Time from onset to hospitalization(d) â‘ 

4.44 ± 1.37

3.89 ± 1.26

3.92 ± 1.02

3.81 ± 0.96

0.000

 

Duration of hospitalization(d) â‘¡

8.85 ± 2.46

11.63 ± 5.04

49.51 ± 33.20

4.55 ± 1.91

0.000

 

WBC > 12 × 10 9 (n)

86(45.5%)

121(61.4%)

27(96.4%)

8(88.9%)

0.000

242(57.2%)

Duration of initial fever(d) â‘¡

5.24 ± 1.54

6.33 ± 1.94

8.38 ± 6.42

6.42 ± 2.25

0.012

 

Highest fever temperature (°C) ③

38.76 ± 0.46

38.846 ± 0.62

39.206 ± 0.51

39.07 ± 0.41

0.032

 

Hand or foot rash (n)

173(91.5%)

183(92.9%)

23(82.1%)

6(66.7%)

0.017

385(91.0%)

Oral rash (n)

121(64.0%)

118(59.9)

17(74.6)

4(44.4%)

0.608

260(61.5%)

Buttock rash (n)

76(40.2%)

81(41.1%)

6(21.4%)

2(22.2%)

0.159

165(39.0)

No rash (n)

  

2(7.1%)

1(11.1%)

0.000

3(0.7%)

EV71 (n)

24(12.7%)

47(23.9%)

13(46.4%)

5(55.6%)

0.000

89(21%)

CA16 (n)

49(25.9%)

18(9.1%)

1©(3.6%)

0

0.000

68(16.1%)

Other enteroviruses (n)

12(6.3%)

6(3%)

2(7.1%)

0

0.369

20(4.7%)

Patients with neurological dysfunction upon discharge (n)

0

2®(1%)

11(39.3%)

 

0.000

13(3.1%)

  1. ①There is statistically significant difference between general group and the other 3 groups but no difference in comparison to the other 3 groups. ②There is statistically significant difference between all groups. ③There is no difference between general groups and severely group or critically group and fatal group, but there is significant difference between each one of the former and the latter two groups. # There was no repeat counting in calculating the distribution of disease types. When neurogenic pulmonary edema or shock and brain stem encephalitis coexisted in the same patient, the former was counted. When neurogenic shock and pulmonary edema coexisted, pulmonary edema was counted. §The denominator of the fraction represents the cases examined, whereas the numerator represents the number of patients with this abnormality. ¤Among the 5 fatal cases, 2 died of neurogenic pulmonary edema, 2 died of shock and 1 patient was declared brain-dead
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Virology Journal

ISSN: 1743-422X