The evolution of human influenza A viruses from 1999 to 2006: A complete genome study

Table 3 Non-synonymous/synonymous substitution ratio for H3N2 and H1N1 isolates sampled in Denmark from 1999 to 2006*

* dN/dS is the ratio of nonsynonymous vs. synonymous substitutions calculated by SLAC likelihood analysis.
^a The internal genes of H1N1 viruses were not included due to the few sequences available (Na). H3 n = 204, N2 n = 166, internal genes n = 15, H1 n = 27, N1 n = 30.
^b dN/dS for PB1-F2 was not included because the method used was biased by the PB1-F2 +1 reading frame from PB1. Synonymous substitutions in PB1 would therefore be assigned as non-synonymous in PB1-F2 not reflecting positive selection on the PB1-F2 itself.

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