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Table 1 Amino acid changes in H3N2, H1N1 and H1N2 viruses between seasons *

From: The evolution of human influenza A viruses from 1999 to 2006: A complete genome study

H3

N2

H1

N1

Amino acid

1999–00

2001–02

2002–03

2003–04

2004–05

2005–06

Amno acid

1999–00

2001–02

2002–03

2003–04

2004–05

2005–06

H1N2

Amino acid

H3 no.

2000–01

2004–05

2005–06

H1N2

Amino acid

N2 no.

2000–01

2004–05

2005–06

5

V

G

G

G

G

G

18

A

 

S(A)

A(S)

S

S

 

43

53

L(R)

L

L

L

15 Pa

15

V/I

I

I

25

L

 

I(L)

I

I

I

19

T

      

47

56

I(T)

I

I

I

23

23

M/I

M

M

33

H

Q

Q

Q

Q

Q

23

L

 

F(L)

L(F)

F

F

 

57

66

V(I)

I

I

I

45 Pb

49

H/Y

H

H

45 c

S

  

I(S)

  

24

M

     

T

69 Cb

78

L(S)

L

L

L

48

52

I(V)

I

I

50 c

R

 

G(R)

G(E)

G

G

30

V

 

I(V)

V(I)

I

I

 

71

80

I(F)

I

I

I

52

56

R/K

R

R/K

56

H

 

H(Y)

   

40

Y

  

H(Y)

   

80

88

V(A)

V

V

V

59

63

S/R

S

S

75 E

H

 

Q(H)

Q

Q

Q

42

C

 

F(C)

C(F)

F

F

 

86

93

E(K)

E

E

E

64

68

H/Q

H

H

83 E

E

 

K(E)

K

K

K

44

S

    

S(P)

 

89

96

T

  

A(T)

75

79

V(I)

V

V

92 E

T

K

K

K

K

K

65

I

I(T)

     

94

100

Y

 

H

 

81 Pc

81

T/P

T

T

106

A

V

A(V)

   

93

N

  

N(D)

D

S(N/D)

 

120

124

D(E/G)

E

E

E

83

83

V/M

V

V

112

V

   

I(V)

V(I)

143

G

 

V(G)

G(V)

V

V

 

130

134

-(K)

-

-

-

93

93

S/P

S

S

126 a

N

  

D(N)

  

150

H

    

H(G)

 

133

136

S(T)

S

S

S

94

94

I

 

I/V

128 b

T

 

A(T)

   

172

K

R

K(R)

R(K)

   

146

149

R(K)

R

R

R

95

95

S/R

S

S

131 a

A

 

T(A)

T

T

T

194

V

    

V(I)

 

153 Sb

156

G(E)

G

G

G

149

149

V(I)

V

V

144 a

I

D

N(D)

N(D)

N

N

199 b

E

  

K

K

K

K

163 Sa

166

K(M)

K

K

K

155

155

Y/F

Y

Y

145 a

K

   

S/N

N

216

G

 

V(G)

G(V)

V

V

 

166 Ca1

169

V(A)

A

A

A

173

172

K/R

K

K

155 b

H

 

T(H)

T

T

T

221 b

K

K(N)

  

K(D/E)

E

 

168

171

N(K)

N

N

N

188 Pd

187

M/L

M

M

156 b

Q

 

H(Q)

H

H

H

258

E

     

K

170 Ca1

173

E(G)

E

E

E

220

219

K

K(E)

K

159 b

Y

  

Y(F)

F

F

265

T

I

 

T(I)

I(T)

  

175

177

L

  

I

222

221

Q(R)

R

R

164

L

L(Q)

    

267

L

T

T

T

T

T

T

179

181

V

 

V(I)

 

249 Pf

248

G/R

G

G

173 D

K

   

E(K)

E(K)

307

V

 

I(V)

V(I)

I

I

 

183

186

P(S)

P

P

P

254

253

K/R

K

K

186 b

S

G

G

G

G

G

310

Y

    

Y(H)

 

185

188

I(M)

I

I

I

262

261

K/R

K

K

188 b

D

   

D(Y)

 

329 c

N

   

N(T)

N(D)

 

187

190

D(N)

D

D

D

270

269

N/D

N

N

189 b

S

  

S(N)

N

N

332 c

S

F

S(F)

F(S)

   

190 Sb

193

A

  

T

274

273

F/Y

F

F

193 b

S

    

F(S)

370 c

L

    

S(L)

 

191

194

L(I)

L

L

L

332 Pi

332

E

K

K

199

S

    

S(P)

372

S

   

S(L)

S(L)

 

194

197

T(K)

T

T

T

344 Pj

347

D(N)

D

D

202

V

 

I(V)

I

I

I

385 a

K

 

N(K)

K(N)

N

N

 

202

205

V(L)

V

V

V

352 Pk

355

K/R

K

K

222

W

 

R(W)

R

R

R

392 a

I

I(T)

     

215

218

A

  

T

364

367

S(N)

S

S

225

G

 

D(G)

D

D

N(D)

393 a

N

 

N(K)

    

237 Ca1

240

G

 

G/R

 

389 Pm

397

M/V

V

V

226 D

V

   

I

I

399 a

D

E

D(E)

E(D)

   

239

242

T(S)

T

T

T

396 Pm

399

I/M

I

I

227 D

S

  

S(P)

P

P

401 a

G

     

D

252

255

W

R

R

W

418

418

I/M

I

I

271

N

D

D

D

D

D

431

K

     

N

253

256

Y

F

F

Y

432 Pn

432

R(K)

R

R

304 c

A

A/P

A(P)

   

432

Q

E

Q(E)

E

E

E

 

267

269

T(I)

T

T

T

450

450

N

D

D

347

V

M

V(M)

   

437

L

W

L(W)

W(L)

   

271

273

P(S)

P

P

P

452

452

D/E

D

D

361

T

   

I

I

        

273

275

D(G)

D

D

D

     

375

N

   

D(N)

D(N)

        

310

312

A(T)

A

A

A

     

386

E

 

G(E)

G

G

G

        

315

317

V

A

V

V

     

450

R

    

R/K

        

321

323

I(V)

I

I

I

     

452

R

K

K

K

K

K

        

345

347

V(I)

V

V

V

     

479

G

 

E(G)

           

382

384

V(I)

V

V

V

     

529

V

I

V(I)

           

398

400

N

S

N

N

     

530

V

 

A(V)

A

A

A(V)

        

451

453

S(T)

S

S

S

     
               

473

475

N

D

D

N

     
               

491

493

E(K)

E

E

E

     
               

506

508

E

  

D

     
               

510

511

V(I)

V

V

V

     
  1. * Amino acids in brackets indicate less than half but more than two substitutions at the given amino acid position within a season. A single amino acid change in one position is not shown. Amino acids separated by '/' indicate equal substitutions of either amino acid at the given position. Letters in upper case above an amino acid indicate the antigenic site location of the residue. In N1 the upper case letter 'P' stands for phylogenetically important region (PIR) and the following letters indicate the actual PIR.
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Virology Journal

ISSN: 1743-422X