From: Regulation of gene expression by microRNA in HCV infection and HCV–mediated hepatocellular carcinoma
miRNA | Target | Function | |
---|---|---|---|
miRNAs that promote HCV replication | miR-122 | HCV 5'-UTR | Promote HCV replication [34, 40, 41] and IRES mediated HCV translation [52] |
SOCS3 | Enhance methylation at SOCS3 gene promoter, inhibits IFN-induced ISRE activity [51] | ||
Cyclin G1 | Promote viral replication induced by alcohol [54] | ||
Xrn1 | Inhibit 5′decay of HCV RNA [55] | ||
miR-141 | DLC | Up-regulated in HCV infection [35] | |
miR-130a | IFITM | Inhibits type I IFN signaling and promote HCV replication [36] | |
miR-21 | MyD88 and IRAK1 | Negatively regulate IFN signaling [62] | |
miRNAs that inhibit HCV replication | miR-196 | NS5A region in HCV genome | Inhibition of HCV replication [37] |
BACH1 | Inhibits HCV RNA and NS5A protein expression [63] | ||
miR-448 | Core region of HCV genome | Inhibition of HCV replication [37] | |
let-7b | NS5B and 5'UTR regions in HCV genome | Reduces HCV infectivity [38] | |
BACH1 | Repression of HCV expression [64] | ||
miR-199a | HCV 5'-UTR | Inhibits viral replication [39] | |
miR-130a | IFNα/IFN β ? | Inhibits HCV RNA replication by increased expression of IFN-α/IFN- β and the ISGs [61] |