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Table 4 The viral load, levels of inflammatory markers and lymphocyte subsets of the study subjects according to disease severity of COVID-19 during hospitalization

From: Viral loads, lymphocyte subsets and cytokines in asymptomatic, mildly and critical symptomatic patients with SARS-CoV-2 infection: a retrospective study

Laboratory findings

Disease severity of COVID-19

Statistic parameter

(mean ± SD)

AS (n = 11)

MS (n = 26)

SCS (n = 11)

F value

P value

Ct values

29.9 ± 2.4

30.4 ± 1.9

31.5 ± 1.5

2.186

0.061

B cells (%)

15.0 ± 9.9

11.5 ± 7.0

4.0 ± 3.2

7.017

0.002**

NK cells (%)

9.8 ± 20.9

3.9 ± 2.9

3.4 ± 1.2

1.284

0.285

CD3 + T cells (%)

69.7 ± 9.9

62.7 ± 9.1

54.7 ± 13.9

5.640

0.007**

CD3 + CD4 + T cells (%)

37.5 ± 10.3

40.1 ± 7.9

31.6 ± 104

3.327

0.045*

CD3 + CD8 + T cells (%)

23.1 ± 6.3

24.2 ± 10.5

17.0 ± 5.6

5.315

0.008**

CD4 + /CD8 + ratio (%)

1.7 ± 1.3

2.3 ± 1.1

2.0 ± 0.9

1.219

0.305

IL2 (pg/mL)

5.4 ± 3.9

3.9 ± 3.6

6.7 ± 5.6

1.805

0.176

IL4 (pg/mL)

9.27 ± 20.9

3.9 ± 3.6

6.7 ± 5.6

1.335

0.273

IL5 (pg/mL)

6.7 ± 8.3

5.3 ± 5.6

5.8 ± 5.2

0.197

0.822

IL6 (pg/mL)

12.3 ± 18.4

6.1 ± 12.5

574.9 ± 1325.4

3.389

0.039*

IL8 (pg/mL)

132.5 ± 114.4

33.5 ± 43.7

869.7 ± 1927.2

3.374

0.043*

IL10 (pg/mL)

2.9 ± 1.1

2.7 ± 1.2

7.4 ± 7.5

6.525

0.003**

TNF-α (pg/mL)

30.9 ± 28.9

25.5 ± 38.0

15.2 ± 24.2

0.639

0.533

INF-α (pg/mL)

5.7 ± 9.3

4.7 ± 6.4

3.3 ± 0.8

0.380

0.686

INF-γ (pg/mL)

12.4 ± 24.0

19.2 ± 48.7

11.7 ± 8.7

0.211

0.810

  1. One‐way analysis of variance. Statistically significant, *P < 0. 05, **P < 0.001
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Virology Journal

ISSN: 1743-422X