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Table 1 Baseline characteristics of the subjects in study

From: Identification and characterization of lncRNA AP000253 in occult hepatitis B virus infection

 

Discovery phase

Validation phase

HCs (n = 10)

OBI (n = 10)

P

HCs (n = 20)

OBI (n = 64)a

ASC (n = 20)

CHB (n = 31)b

P

Demographic characteristics

 Female (n, %)

1 (10.00)

2 (20.00)

0.53

6 (30.00)

22 (34.38)

7 (35.00)

10 (41.94)

0.98

 Age (years)

39.30 ± 11.68

42.80 ± 7.96

0.45

38.00 ± 7.94

42.86 ± 8.81

36.00 ± 7.48

43.11 ± 14.16

0.09

Serological characteristics

 ALT (U/L)

19.56 ± 7.63

22.70.67 ± 11.14

0.48

16.74 ± 6.41

18.99 ± 9.79

37.80 ± 8.23

219.94 ± 263.70

0.13

 HBsAg (S/CO, positive)

0.31 ± 0.30

0

0.12 ± 0.16

0

0.12

0.21 ± 0.25

0

0.16 ± 0.21

0

22.89 ± 9.91

20

272.28 ± 139.62

31

< 0.01c

 Anti-HBs (S/CO, positive)

7.00 ± 8.32

5

0.87 ± 0.72

3

0.04

8.24 ± 8.18

12

0.77 ± 1.21

7

0.21 ± 0.24

0

0.23 ± 0.72

0

< 0.01c

 HBeAg (S/CO, positive)

0.08 ± 0.03

0

0.07 ± 0.02

0

0.89

0.07 ± 0.01

0

0.05 ± 0.02

0

0.06 ± 0.01

0

38.91 ± 82.97

7

0.46c

 Anti-HBe (S/CO, positive)

1.60 ± 0.31

0

1.28 ± 0.47

2

0.11

1.88 ± 0.12

0

0.97 ± 0.40

8

0.24 ± 0.34

19

8.53 ± 30.90

24

< 0.01c

 Anti-HBc (S/CO, positive)

1.48 ± 0.47

1

0.71 ± 0.73

7

0.02

1.96 ± 0.40

0

0.45 ± 0.53

28

0.08 ± 0.07

20

11.03 ± 1.84

31

< 0.01c

 HBV-DNA (Ct)

NA

34.89 ± 1.25

NA

NA

35.86 ± 1.87

33.67 ± 3.01

23 ~ 2.88E + 8

< 0.01c

  1. OBI occult HBV infection, CHB chronic hepatitis B, ASC asymptomatic HBsAg carriers, HC healthy controls, HBsAg hepatitis B surface antigen, Anti-HBs antibody for HBsAg, HBeAg hepatitis B envelope antigen, Anti-HBe antibody for HBeAg, Anti-HBc antibody for hepatitis B core antigen, ALT alanine aminotransferase, Ct cycle threshold, NA not available
  2. aDue to limited volume, the results of Anti-HBs, HBeAg, Anti-HBe and Anti-HBc were only available for 34 OBI samples
  3. bHBsAg, Anti-HBs, HBeAg, Anti-HBe and Anti-HBc were measured with Anytest-2000 TRF detection system, and HBV DNA was detected with HBV DNA PCR-fluorescence quantitative diagnostic kit(KHB)
  4. cP value indicated the statistic differences between HCs, OBI and ASC groups