Table 2 Performance of the Well assay according to the reference results of the Abbott assay
From: Evaluation of a new point-of-care oral anti-HCV test for screening of hepatitis C virus infection
Well oral anti-HCV assay | Serum anti-HCV (Abbott assay) (n = 1179) | ||||||||
|---|---|---|---|---|---|---|---|---|---|
Center 1 (n = 351) | Center 2 (n = 345) | Center 3 (n = 483) | Centers 1–3 | Total | |||||
Positive | Negative | Positive | Negative | Positive | Negative | Positive | Negative | ||
Positive, n | 109 | 4 | 91 | 8 | 241 | 2 | 441 | 14 | 455 |
Negative, n | 3 | 235 | 12 | 234 | 24 | 216 | 39 | 685 | 724 |
Total | 112 | 239 | 103 | 242 | 265 | 218 | 480 | 699 | 1179 |
Sensitivitya (%) (95% CI) | 97.32(91.79,99.31) | 88.35(80.16,93.57) | 90.94(86.66,93.99) | 91.88(88.97,94.09) | |||||
Specificitya (%) (95% CI) | 98.33(95.48,99.46) | 96.69(93.35,98.45) | 99.08(96.37,99.84) | 98.00(96.58,98.86) | |||||
PPVa (%) (95% CI) | 96.46(90.65,98.86) | 91.92(84.24,96.19) | 99.18(96.74,99.86) | 96.92(94.77,98.24) | |||||
NPVa (%) (95% CI) | 98.74(96.06,99.67) | 95.12(91.42,97.34) | 90.00(85.31,93.36) | 94.61(92.64,96.09) | |||||
Accuracya (%) (95% CI) | 98.01(95.86,99.11) | 94.20(91.17,96.26) | 94.62(92.20,96.33) | 95.50(94.16,96.56) | |||||
Kappa valuea | 0.954 | 0.860 | 0.892 | 0.906 | |||||