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Table 1 Laboratory confirmation of the pathogenic agent in this outbreak*

From: An outbreak of aseptic meningitis caused by coxsackievirus A9 in Gansu, the People's Republic of China

Cases

Molecular detection

Serology detection

 

Direct RT-PCR for pan-enterovirus

Virus isolation/serotyping

ELISA testing for Coxsackievirus IgM of 22 acute-phase sera

Neutralization Test

 

CSF

Stool

CSF

Stool

 

Neutralization titer in acute-phase

Neutralization titer in convalescent

1

+

+

+/CVA9

+/CVA9

+

<1:20

1:501

2

+

+

-

-

+

<1:20

1:1000

3

+

+

-

+/CVA9

+

<1:20

>1:1024

4

+

/

+/CVA9

/

-

/

/

5

-

+

-

+/CVA9

+

/

/

6

-

+

-

+/CVA9

+

/

/

7

-

+

-

+/CVA9

+

/

/

8

-

+

-

+/CVA9

+

/

/

9

-

+

-

-

+

/

/

10

-

+

-

-

-

/

/

11

/

+

/

-

-

/

/

12

/

+

/

-

-

/

/

13

/

+

/

-

-

/

/

14

/

-

/

-

+

/

/

15

/

-

/

-

+

/

/

Total

4

12

2//CVA9

6//CVA9

10

At least four times higher for all three pairs of paired serum samples

  1. * this table only showed the positive results of 22 cases in this outbreak;
  2. / showed no specimens obtained in this outbreak.