Table 1 Demographic, clinical and socioeconomic characteristics of the children with A/H1N1 influenza infection, by the presence or absence of the H275Y mutation.
Characteristics | Oseltamivir-resistant seasonal A/H1N1 influenza virus (n = 19) | Wild-type seasonal A/H1N1 influenza virus (n = 124) |
|---|---|---|
Demographic data | ||
No. of males (%) | 11 (57.9) | 73 (58.9) |
Mean age ± SD, years | 4.33 ± 3.61 | 3.39 ± 2.58 |
Previous use of neuraminidase inhibitors, no. (%) | 0 (0.0) | 0 (0.0) |
CT, mean ± SD | 25.48 ± 4.44 | 26.94 ± 4.57 |
Clinical presentation | ||
Common cold, No. (%) | 4 (21.0) | 28 (22.6) |
Pharyngitis, No. (%) | 5 (26.3) | 34 (27.4) |
Acute otitis media, No. (%) | 3 (15.8) | 18 (14.5) |
Acute bronchitis, No. (%) | 4 (21.0) | 26 (21.0) |
Pneumonia, No. (%) | 1 (5.3) | 8 (6.5) |
Gastroenteritis, No. (%) | 1 (5.3) | 6 (4.8) |
Fever without source, No. (%) | 1 (5.3) | 4 (3.2) |
Clinical outcome | ||
Hospitalisation, No. (%) | 4 (21.0) | 21 (16.9) |
Median number of lost school days (range) | 6 (1-12) | 5 (1-10) |
Pharmacological treatment | ||
Antibiotics, No. (%) | 13 (68.4) | 88 (70.9) |
Antivirals, No. (%) | 0 (0.0) | 0 (0.0) |
Antipyretics, No. (%) | 16 (84.2) | 99 (79.8) |
Socioeconomic impact on households | ||
Similar disease among family members, No. (%) | 10 (52.6) | 52 (41.9) |
Hospitalisations, No. (%) | 1 (5.3) | 0 (0.0) |
Median number of lost parental working days (range) | 3 (1-11) | 3 (1-9) |
Median number of lost sibling working days, (range) | 4 (2-14) | 3 (2-15) |