Hepatitis C virus core, NS3, NS4B and NS5A are the major immunogenic proteins in humoral immunity in chronic HCV infection

Table 2 Hepatitis C virus genotype-specific antibody responses against nine recombinant HCV proteins.

		Percentage of positive sera of each genotype
Genotype	n	Core	E1	E2	NS2	NS3	NS4A	NS4B	NS5A	NS5B
1	21	95	43	52	0	90	52	95	57	0
2	20	95	20	25	0	50	15	70	50	0
3	23	100	4	13	0	67	13	87	52	13
4	4	100	25	50	0	50	25	100	25	0

The prevalence of anti-HCV antibodies were analysed by Western blot analysis with recombinant HCV proteins in 68 patients with chronic HCV infection caused by different genotypes 1, 2, 3 and 4. The data is presented as the percentage of tested sera in each genotype that showed antibody response against a given HCV protein. The number of analysed sera for each genotype is shown as n.

ISSN: 1743-422X